Asperger's Syndrome in a syndrome in individuals that is typified by talking a lot, usually about a favorite subject in one-sided conversations in which the one with Asperger’s will not admit the possibility that he is wrong. People with Asperger’s also lack empathy, do not pick up on social cues and may lack inborn social skills, such as being able to read others' body language, recognize subtle differences in speech tone, pitch, and accent that alter the meaning of others, speech may be flat and ...