Congenital syphilis occurs when a mother's syphilis goes untreated during pregnancy and is passed to the baby through the placenta. A baby can also become infected with syphilis during labor or delivery.
The risk of infecting the baby is greatest when the mother is in the early stages of syphilis; however, infection is possible any time during pregnancy.1
It is very important that a pregnant woman have a lab test to detect syphilis. The baby's risk of getting syphilis is significantly reduced if the mother receives treatment during pregnancy. If the mother is treated before the 16th week of her pregnancy, the baby will usually not become infected. Treating a pregnant woman in the secondary stage of syphilis before her last month of pregnancy reduces the chances the baby will be born with congenital syphilis by 98%. 2
If an infected mother does not receive treatment, the mother may miscarry, or the baby may be born dead, die shortly after birth, be born early, or be infected with syphilis.1
Complications that can occur in a baby whose infected mother was not treated include:
A flat bridge of the nose (saddle nose).
Permanent incisor teeth that are peg-shaped, widely spaced, and notched at the end with a crescent-shaped deformity in the center (notched teeth or Hutchinson's teeth).
Inflammation of the cornea, which may cause blindness (interstitial keratitis).
A progressive, disabling, and life-threatening complication involving the brain (neurosyphilis).
Deafness.
Bone deformities.
Antibiotics can prevent progression of the disease in an infected baby. However, problems that have already developed may not be reversible.
If a baby with syphilis is not treated, the disease can progress to a late congenital stage, if the baby lives past the first 6 to 12 months.
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Late syphilis; Tertiary syphilis
Definition Return to top
Tertiary syphilis is a late phase of the sexually transmitted disease syphilis, caused by the spirochete Treponema pallidum.
Causes
Tertiary syphilis can follow the initial infection, primary syphilis, by 3 to 15 years. Secondary syphilis is the stage that precedes tertiary syphilis if primary syphilis is not treated.
In tertiary syphilis, the spirochetes have continued to reproduce for years. Pockets of damage accumulate in various tissues such as the bones, skin, nervous tissue, heart, and arteries. These lesions are called gummas and are very destructive.
Lesions in the central nervous system produce neurological disease called neurosyphilis which can include tabes dorsalis, general paresis, and optic atrophy. Lesions of the heart, heart valves and aorta can lead to aneurysms, valvular heart disease, and aortitis.
Tertiary syphilis is less frequently seen today than in the past because of early detection and adequate treatment.
Symptoms of tertiary syphilis depend on which organ systems have been affected. They vary widely and are difficult to diagnose. In individuals with tertiary syphilis the primary and secondary stages of syphilis usually have been long forgotten. Medical findings of aortic aneurysms and neurological problems require astute diagnostic ability to link them to syphilis. Some of the symptomatic problems are listed below.
Infiltrative tumors of skin, bones, or liver (gumma)
Cardiovascular syphilis which affects the aorta and causes aneurysms or valve disease
Central nervous system disorders (neurosyphilis)