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Perhaps not caring about your audience can lead to great works of art at times?
When you say "not caring about your audience", are you refering to an artist that does not produce deliberately for a defined public, or do you mean one who is not preoccupied about producing something which could appeal for the common reader? William Blake for instance was unpopular in his time, the majority of his works being concerned with his personal mithology and unorthodox spiritual views, but I doubt he did not wrote his poetry with its aesthetic consistency in mind. Kafka and Dickinson wrote primarily for themselves, but even in their works there is an evident care with the form and the artistic coherence.