Random Mutation -- Is Occam's Razor the best evidence?
A brief search for evidence for random mutation's key role in evolution led me to discover this web page from a website called "Evolution 101" provided by UC-Berkeley.
http://evolution.berkeley.edu/evosit...1aRandom.shtml
The article mentions that there is no unambiguous evidence of NON-random mutation (no surprise there). Further, the final paragraph points to research indicating that mutations that are beneficial in a particular environment can be present in the organism even before the organism is exposed to the particular environment. This seems like very strong evidence that the mutations are not a purposeful response to the environment.
It immediately reminded me of how there has turned out to be a certain segment of people who are immune to the AIDS virus. It seems extremely unlikely that this particular immunity in these individuals results from purposeful genetic mutation in the mere decades since the arrival of AIDS. The gene is undoubtedly present in many individuals who have never been exposed to the AIDS virus.
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UNFORTUNATELY, my curiosity in this AIDS-resistance led me to this article, which points out that beneficient mutations pre-existing in AIDS-immune individuals are probably the result of a resistance to some previously-existing form of smallpox.
http://www.wired.com/medtech/health/news/2005/01/66198
This analysis would seem to cast doubt on the (impressive to me, just moments earlier) evidence provided at the UC-Berkeley website. (Perhaps the antibiotic resistance pre-existing in the bacteria discussed there was the result of a previous exposure to a similar anti-biotic...). I kept looking into this issue, until encountering scholarly articles that are way out of my league.
This leaves me wondering what the evidence for random mutation's key role in evolution actually is. Both websites mentioned above seem to go to certain lengths to point out that research in this area is continuing, and that a certain amount of debate continues, at least regarding certain points. So far, I haven't been able to find any conclusive evidence for the randomness of beneficial genetic mutation--only evidence of beneficial pre-existing mutations, which might have resulted from previous exposures to similar environmental challenges in the past.
At this point, it seems to me that the best 'evidence' for random mutation's key role in evolution would be an "Occam's Razor"-type argument: Random mutation can theoretically do the job, so why would we need to posit a mechanism for purposeful mutation? But there might be much better, more direct evidence out there somewhere. I'm just kind of worried that it exists only in scholarly articles.
Can someone help me find a simple, clear example of evidence for the randomness of beneficial mutations? (Something better than a mere assertion in a biology textbook). The last thing I expected was that it would be so difficult to find it.