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The two lines quoted above constitute the crux of the poem. “The stars” can be taken as the rebel angels. Therefore lines 17-18 above can be interpreted when the rebel angels in Heaven surrendered to the power of God, which is represented by the tiger in this poem, and when they wept with humiliation (and when God proceeded to create the earth and its inhabitants—among them the tiger). The reference in lines 17-18 is, therefore, to the defeat of the rebel angels led by Lucifer (Satan), after which came the Creation. It is thought that the lines quoted above refer to the fall of the angels as described by John Milton in Paradise Lost:
They, astonished, all resistance lost,
All courage, down their weapons dropt.
In Blake conception, when the fallen angels were driven into hell, they “watered heaven with their tears” leaving them behind as stars. All of this has obvious relationship with the fall of man, and the introduction into the world of death, and such terrors as the tigers. The angels and man have fallen into Experience.