I have no sense of that at all, I have to say.
I can understand that. I'm not saying I have much of a sense of it myself except as an intellectual idea. My - our - daily focus seems to be a back and forth of happiness/ unhappiness, and I haven't directly realised this as a truth. At the moment I'm a mere regurgitator, though I have reason to go with it.
the universe doesn't really recognise life in general as very significant, and actually has no mechanism even to consider whether individual lives are important - which means, actually, that they're not.
I - cautiously - think the view is from a different perspective. Our scientific worldview suggests a concrete external world and universe in which we're a tiny part as you indicate.
I think the Buddhist worldview has a different perspective in that reality is created by our minds and the minds of others which establish a seemingly real externality.
The difficulty is that both are valid (Called The Two Truths). It is simple for you to prove to me that the world exists as we perceive it - and I know this and wouldn't argue. The other perspective involves an understanding - through direct insight - into Emptiness - the essential Emptiness of all phenomena. It's to do with the idea that things - people, objects, ideas - have a dependant reality and not an independant one. If things have a dependant reality - so the thought goes - then they do not exist - as we perceive them - as independant objects - but in another way. In short our perception of the universe around us is false. (This is not a proper explanation of Emptiness - I'm unqualified to explain it so I can't really go further with it. I'm not being evasive, but it would be wrong to give a false impression or pretend that I understand it in a way that can explain it to others).
This is a big claim - I can feel the scientists converging upon me as I speak -but may explain the irreconcilability of science and religion.
To get back to your quote - then it thus places us -or rather our minds and other's minds - at the heart of the creation of the external world - (mixed with Karma) - and therefore more important than a scietific view would have us.
The upshot, though, is that sometime in my thirties, circumstances conspired to encourage me to figure out what the **** was going on inside me, and so I worked on it. Having recognised a sort of subterranean magma flow that fuelled all the tectonic shifts on the surface, I realised that whatever was going on under there was fundamental, and that as long as I was aware of it, I could anticipate the crevasses, and step over them or step away - and, eventually, learn to dance in time with the shifts and quakes.
All of which, of course, makes you much more sympathetic to the mad volcanoes on other people's planet
That's good. I'm still struggling with mine. The Grumbler is still strong. I have been impetuous in the past and could have potentially caused myself a great deal of trouble if things had turned out differently. Sometimes upsetting the apple cart can put you on a new and even better path, but I reckon when that happens there's something else going on too.

