What are some concepts and values associated with the villain(s) within Macbeth?

I can't think of more than one.
A pretty obvious one is of Lady macbeth, and her issues with femininity, and how it was viewed badly for a lady to act like man.

But what else?
Please help :S

Another is Macbeth's hypnotising ambition, his fear and compunction and, ultimately, his uncompromising bloodymindedness.