Unfulfillment and selfdestruction

[Inferna]

What novels and stories are directly concerned with unfulfillment and selfdestruction?

[kelby_lake]

Chekhov's plays are all about unfulfilment. In fact, isn't that what most literature is about?

[Trask]

Death of a Salesman is. Both in a literal and figurative sense

[Charles Darnay]

Beautiful and the Damned

[dysfunctional-h]

Too many to count. The Yellow Wallpaper, The Sound and the Fury, Death in Venice, 1Q84, and Of Mice and Men, just to name a few.