In Ohio, she met Calvin Stowe, a professor of Biblical Literature at Lane and clergyman who fervently opposed slavery. He was nine years her senior and the widower of her dear friend, Eliza Tyler. They married in 1836 and eventually had seven children, four of whom died during her lifetime.
Samuel Charles, "Charley" died at eighteen months from cholera and an older son,
Henry, drowned while a student at Dartmouth College.
Years later, their son Frederick, an alcoholic from the age of sixteen, died, never really recovering from the wounds he sustained at Gettysburg in the Civil War nor being able to cope with his mother's success.
Daughter Georgiana, married to an Episcopal priest and a mother, died in her forties, having lost her health and mind to morphine addiction.
Twin daughters, Eliza and Isabella, and a son, Charles Edward lived and were comforts to their parents.