I have wrestled with this topic for quite awhile. I believe that the Bible is clear for its time, that wine was drunk by many. And not because water was scarce. What did they fill up at the marriage in Cana: water barrels. Water they had plenty of, it was wine they were short on! On the other hand, excess alcohol is a toxin, and hurts the body, which is the temple of the Living God. God is not at all happy with human vices which take people's mind off serving Him, or take their bodies out of commission. Hard to go to church in the morning w/ a hangover.
Jesus drank wine. He compared himself to John the baptist. John, he said in Luke 7, came neither eating bread nor drinking wine; whereas he, the Son of man, came eating and drinking. John wasn't trying to avoid grape juice, he was abstaining from alcohol. Wine in and of itself cannot be spiritually evil. Matthew 15:11 "...not that which goeth into the mouth defileth a man; but that which cometh out of the man..."
We need to ask ourself in each situation, why do we desire to drink wine (or beer, or other substances). That should be what tells us it's ok or not, how we feel about the motivations and the truthfulness with which we face up to them (even if only to ourselves). I think a spiritually healthy attitude is understanding that there may be some times when something is ok, and other times when it isn't. My belief is that Jesus would handle the topic of alcohol on a case by case basis. The Bible is clear that certain things are absolutely against God, and it amazes me that church-run institutions would take a stand against drinking wine - but allow, for example, divorced people to remarry.