Without a doubt, the greatest Novel written by an American is The Ship that Sailed the Time Stream by G. C. Edmonson. It covers everything from top to bottom, and it is fun to read. Another candidate is Causation by Peter P. Lewicke. That also covers almost everything, and it is a pleasure to read.
https://www.amazon.com/Ship-That-Sai.../dp/044176097X
https://www.amazon.com/Causation-Pet...s=books&sr=1-1